What is the primary indication of Clomiphene citrate (Clomid) for women seeking treatment?

Clomiphene citrate, commonly referred to as Clomid, is primarily indicated for the induction of ovulation in women who are experiencing infertility due to anovulation or oligoovulation. The medication works as a selective estrogen receptor modulator, which stimulates the release of hormones necessary for ovulation by blocking estrogen receptors in the hypothalamus. This increase in gonadotropin-releasing hormone then leads to an increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secretion, promoting the growth and release of ovarian follicles.

This mechanism is critical for women with conditions such as polycystic ovary syndrome (PCOS) or other disruptions in their normal ovulatory function, making Clomid a key first-line treatment in these scenarios. While Clomiphene might have some off-label uses, such as potentially influencing early pregnancy outcomes in certain cases, its primary and well-established role remains centered on assisting in ovulation induction. This is why it is the most appropriate choice regarding the indications for Clomiphene citrate.