What should be done for a woman at risk of toxoplasmosis with a negative titer during pregnancy?

For a woman at risk of toxoplasmosis who has a negative titer during pregnancy, the most appropriate response is to take no specific action during pregnancy. A negative titer indicates that the woman has not been exposed to the Toxoplasma gondii parasite and thus is not currently infected. As a result, she is not at risk of transmitting the infection to her fetus.

Being at risk primarily relates to potential exposure to sources of the parasite, such as undercooked meat or cat feces. The absence of specific symptoms or a positive titer means that the woman does not require further intervention or treatment at this point. Monitoring and education about avoiding potential sources of exposure are typically recommended, but these measures do not require immediate action.

Conversely, options such as vaccination, use of antiprotozoal medications, or termination of pregnancy are not indicated for a woman who remains uninfected, as there are currently no effective vaccines for toxoplasmosis in humans, and treatment is only warranted for confirmed cases of infection or symptomatic individuals.